Gene information
Official symbol MMP1
Official full name matrix metallopeptidase 1
Gene type protein-coding gene
Chromosome11q22.2
Previous symbolCLG
Gene familyReceptor ligands; M10 matrix metallopeptidases
Resources
Entrez Gene 4312
HGNC HGNC:7155
Ensembl ENSG00000196611
Vega OTTHUMG00000048192
UCSC uc001phi.3
GO terms: 29 records
GO Description Category LogP Number of genes Detail
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0004222 metalloendopeptidase activity GO Molecular Functions -10.6700212 15 More
GO:0004252 serine-type endopeptidase activity GO Molecular Functions -24.0834770 30 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008236 serine-type peptidase activity GO Molecular Functions -23.9716175 31 More
GO:0008237 metallopeptidase activity GO Molecular Functions -10.3008607 18 More
GO:0009314 response to radiation GO Biological Processes -9.77450393 26 More
GO:0009411 response to UV GO Biological Processes -7.07745319 13 More
GO:0009416 response to light stimulus GO Biological Processes -4.81054429 15 More
GO:0017171 serine hydrolase activity GO Molecular Functions -24.8900503 32 More
GO:0022411 cellular component disassembly GO Biological Processes -6.34931814 17 More
GO:0022617 extracellular matrix disassembly GO Biological Processes -9.45487411 10 More
GO:0030198 extracellular matrix organization GO Biological Processes -21.4880730 33 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030574 collagen catabolic process GO Biological Processes -13.3732998 12 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031334 positive regulation of protein-containing complex assembly GO Biological Processes -8.84926570 16 More
GO:0032963 collagen metabolic process GO Biological Processes -15.1142156 15 More
GO:0034644 cellular response to UV GO Biological Processes -5.54644403 9 More
GO:0043062 extracellular structure organization GO Biological Processes -21.4370160 33 More
GO:0043254 regulation of protein-containing complex assembly GO Biological Processes -7.63830100 21 More
GO:0044089 positive regulation of cellular component biogenesis GO Biological Processes -10.7794496 56 More
GO:0045229 external encapsulating structure organization GO Biological Processes -21.3355594 33 More
GO:0070141 response to UV-A GO Biological Processes -7.87763977 6 More
GO:0071214 cellular response to abiotic stimulus GO Biological Processes -11.2775864 23 More
GO:0071478 cellular response to radiation GO Biological Processes -4.2266687 10 More
GO:0071482 cellular response to light stimulus GO Biological Processes -4.67282705 9 More
GO:0071492 cellular response to UV-A GO Biological Processes -8.67610245 6 More
GO:0104004 cellular response to environmental stimulus GO Biological Processes -11.2775864 23 More
KEGG pathways: 8 records
KEGG Description Category LogP Number of genes Detail
hsa03320 PPAR signaling pathway KEGG Pathway -10.0668076 12 More
hsa04657 IL-17 signaling pathway KEGG Pathway -16.8039621 19 More
hsa04926 Relaxin signaling pathway KEGG Pathway -10.8215200 16 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05219 Bladder cancer KEGG Pathway -8.60591296 9 More
hsa05323 Rheumatoid arthritis KEGG Pathway -22.3868189 23 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
Drug-Gene interaction
view
Related drugs: 17 records
Drug name Interaction type Source PMID View
apratastat inhibitor TTD view
cipemastat inhibitor TTD view
collagenase clostridium histolyticum TdgClinicalTrial view
doxycycline inhibitor ChemblInteractions view
doxycycline calcium inhibitor ChemblInteractions view
doxycycline hyclate inhibitor ChemblInteractions view
hydrocortisone NCI 7592884 view
lamivudine NCI 15309715 view
leflunomide NCI 16762150 view
leuprolide acetate NCI 9433928 view
marimastat inhibitor TTD 108526381175235210669951 view
medroxyprogesterone acetate NCI 9436888 view
pentosan polysulfate sodium NCI 1384503 view
prinomastat TTD view
ribavirin NCI 16699498 view
sirolimus NCI 16914544 view
triamcinolone NCI 12123742 view
Related studies: 13 records
Molecular factor Omics type Application Objective MI type Reference
NM_002421.4:c.-422A>T genomics adverse events[prognosis (bad)] acute ST elevation myocardial infarction Pavkova Goldbergova M et al. J Appl Genet. 2017
NM_002421.4:c.[-1607insG;-340T>C] genomics myocardial infarction[diagnosis] myocardial infarction Pearce E et al. Circ Res. 2005
NM_002421.4:c.[-1607insG;-340T>C] genomics myocardial infarction[diagnosis] myocardial infarction Pearce E et al. Circ Res. 2005
NM_002421.4:c.[-1607insG;-519A>G;-340T>C] genomics myocardial infarction[diagnosis] myocardial infarction Roman-Garcia P et al. Coron Artery Dis. 2009
interstitial collagenase proteomics left ventricular remodeling[prognosis (bad)] acute ST elevation myocardial infarction Hirohata S et al. Heart. 1997
interstitial collagenase proteomics left ventricular ejection fraction[other] acute myocardial infarction Soejima H et al. Circ J. 2003
interstitial collagenase proteomics congestive heart failure[prognosis (bad)] acute myocardial infarction Ueshima K et al. Magnes Res. 2003
interstitial collagenase proteomics left ventricular dysfunction[prognosis (bad)] acute myocardial infarction Papadopoulos DP et al. Eur Cytokine Netw. 2005
interstitial collagenase proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Suzuki H et al. Eur J Clin Invest. 2008
interstitial collagenase proteomics acute non-ST elevation myocardial infarction[diagnosis] acute non-ST elevation myocardial infarction Tanindi A et al. Open Cardiovasc Med J. 2011
interstitial collagenase proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Tanindi A et al. Open Cardiovasc Med J. 2011
NM_002421.4:c.-519A>G genomics adverse events[prognosis (bad)] acute ST elevation myocardial infarction Pavkova Goldbergova M et al. J Appl Genet. 2017
NC_000011.10:g.102799765C>G genomics myocardial infarction[diagnosis] myocardial infarction Sakowicz A et al. Arch Med Sci. 2010
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